We regularly get asked if that is yes to take it a certain combination of drugs together. That is constantly a great idea to dual check into this case if you are unsure if they space compatible. In our latest question and also answer, we explore taking the combination of Benadryl and Claritin.

You are watching: Can loratadine and diphenhydramine be taken together


Arlene asked

Can i take Benadryl (Diphenhydramine) and also Claritin (Loratadine) together?​​ I want I have poor allergies and need an ext relief.

At a glance

Benadryl and Claritin space antihistamines and also have the same device of action. Benadryl reasons significantly an ext sedation and also only lasts four to six hours while Claritin is non-sedating and lasts 24 hrs per dose. Her doctor might recommend to take Claritin and Benadryl together in specific situations, such as if you are having an allergy reaction.



In many cases, it is not recommended to take Benadryl and Claritin together...but there are some exceptions which we discuss below.<1>

Both Benadryl and Claritin are antihistamine medications and work the same method mechanistically in the body.

They both work by impede what is well-known as the histamine-1 receptor. This prevents histamine from binding to it and also producing the allergy symptom we space all very familiar through (runny nose, stuffy nose, post-nasal drip, etc...).

While they both work the same way, they do have various characteristics. Benadryl is a "first-generation" antihistamine once Claritin is a "second-generation" antihistamine.

First-generation antihistamines are known for your sedative effects and also short expression of action. Top top the other hand, second-generation antihistamines typically last 24 hours per dose and are non-sedating.<2>

Due to the duplicative and also additive nature the Claritin (loratadine) and also Benadryl (diphenhydramine), the usage of both with each other is not recommended.

Benadryl (diphenhydramine) through itself causes pronounced sedation and also this sedation can be somewhat magnified when linked with Claritin (loratadine), although Claritin is considered essentially non-drowsy.

Other additive side results that are feasible include:

Dry mouthDry eyesConstipationUrinary retention

The communication we room worried about is the additive drowsiness when both space taken together. Return as pointed out above, Claritin (loratadine) is non-drowsy, combining it with another antihistamine that works the same method could perhaps reason an additive effect of the two.

In addition, you most likely would not acquire any extr benefit from acquisition Benadryl and also Claritin together.

Each medicine on their own does a pretty great of prevent the histamine receptor and also taking the 2 at when would no produce any type of appreciable distinction from just taking one.

One instance where it may be okay to take it both close to each other is if friend are having actually an allergic reaction.

It is thought (and multiple studies have actually reported) that Benadryl is contempt more effective in ~ stemming an allergy reaction (such regarding a bee sting) 보다 second-generation antihistamines prefer Claritin.<3>

If you take Claritin (loratadine) ~ above a everyday basis for her seasonal allergies and also were in a instance where friend were having a significant allergic reaction, Benadryl (diphenhydramine) may be one appropriate selection to include on before you make it come the hospital.

In a instance like this, I would certainly say it would be yes sir to take it both nearby together and your doctor might recommend it for you.

Your doctor might recommend intermittent usage of the medicine to aid you sleep, only on a short term, "as needed" basis even when utilizing Claritin everyday for allergy prevention.

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Taking both Claritin and also Benadryl together increases the hazard of side effects. You also will not experience far better allergy relief once taking both with each other in most cases.However, studies show that Benadryl may be more effective come treat an allergy reaction, and may be safe and beneficial to take if you space experiencing one, also if girlfriend are already taking Claritin.Benadryl is occasionally recommended as a sleep help to be offered intermittently, also if you already take a everyday antihistamine choose Claritin.
concern At a glance Answer exactly how Benadryl and Claritin work-related Don't take Together? as soon as To Combine an introduction

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in new York State and the founder of the Q+A website PharmacistAnswers.com. He i graduated from the university At Buffalo v a medical professional of Pharmacy degree in 2010.He has been featured in numerous publications including the Huffington Post and also a variety of health and also pharmacy-related blogs.Please feel cost-free to reach the end to him directly if girlfriend have any type of inquiries or desire to connect! He's answered hundreds of medication and also pharmacy-related questions and also he's ready to answer yours!


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